Cooperative effect of polyvinylpyrrolidone and HPMC E5 on dissolution and bioavailability of nimodipine solid dispersions and tablets

Cooperative effect of polyvinylpyrrolidone and HPMC E5 on dissolution and bioavailability of nimodipine solid dispersions and tablets

Solid dispersion (SD) systems have been extensively used to increase the dissolution and bioavailability of poorly water-soluble drugs. To circumvent the limitations of polyvinylpyrrolidone (PVP) dispersions, HPMC E5 was applied in the formulation process and scaling-up techniques, simultaneously. I...

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Bibliographic Details
Main Authors: Zhisu Sun, Huicong Zhang, Huiyang He, Lingling Sun, Xiaorui Zhang, Qun Wang, Kexin Li, Zhonggui He
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Asian Journal of Pharmaceutical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087618302885

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http://www.sciencedirect.com/science/article/pii/S1818087618302885

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