Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis

Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis

Myocarditis is an inflammatory disease of the heart muscle most commonly caused by viral infection and often maintained by autoimmunity. Virus-induced tissue damage triggers chemokine production and, subsequently, immune cell infiltration with pro-inflammatory and pro-fibrotic cytokine production fo...

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Bibliographic Details
Main Authors: Ingmar Sören Meyer, Carl Christoph Goetzke, Meike Kespohl, Martina Sauter, Arnd Heuser, Volker Eckstein, Hans-Peter Vornlocher, Daniel G. Anderson, Jan Haas, Benjamin Meder, Hugo Albert Katus, Karin Klingel, Antje Beling, Florian Leuschner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
inflammation and immunmodulation
innate immunity
cytokines
monocytes/macrophages
RNA interference
virus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02303/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02303/full

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