Impairment of Dendrodendritic Inhibition in the Olfactory Bulb of APP/PS1 Mice

Impairment of Dendrodendritic Inhibition in the Olfactory Bulb of APP/PS1 Mice

Olfactory dysfunction is an early event in Alzheimer’s disease (AD). However, the mechanism underlying the AD-related changes in the olfactory bulb (OB) remains unknown. Granule cells (GCs) in the OB regulate the activity of mitral cells (MCs) through reciprocal dendrodendritic synapses, which is cr...

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Bibliographic Details
Main Authors: Weiyun Li, Shanshan Li, Lianghua Shen, Junbo Wang, Xuewei Wu, Jing Li, Chunlong Tu, Xuesong Ye, Shucai Ling
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
olfactory dysfunction
olfactory bulb
dendrodendritic inhibition
γ oscillations
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00002/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00002/full

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