A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI

A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI

Plasma HDL cholesterol levels (HDL-C) are an independent predictor of coronary artery disease (CAD). We have completed a genome-wide linkage scan for HDL-C in a US cohort consisting of 388 multiplex families with premature CAD (GeneQuest). The heritability of HDL-C in GeneQuest was 0.37 with gender...

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Bibliographic Details
Main Authors: Rong Yang, Lin Li, Sara Bretschger Seidelmann, Gong-Qing Shen, Sonia Sharma, Shaoqi Rao, Kalil G. Abdullah, Kenneth G. MacKinlay, Robert C. Elston, Qiuyun Chen, Eric J. Topol, Qing Kenneth Wang
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Journal of Lipid Research
Subjects:
genetics
linkage
single nucleotide polymorphism
high density lipoprotein cholesterol
coronary artery disease
myocardial infarction
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410181

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http://www.sciencedirect.com/science/article/pii/S0022227520410181

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