Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration

Abstract Wallerian degeneration (WD) involves the recruitment of macrophages for debris clearance and nerve regeneration, and the cause of the foamy macrophages that are frequently observed in peripheral transection injuries is unknown. Recent studies indicated that these foamy cells are generated b...

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Bibliographic Details
Main Authors: Ye Tao, Fang Wang, Zhaohui Xu, Xianfu Lu, Yanqing Yang, Jing Wu, Changyu Yao, Fangzheng Yi, Jiajia Li, Zhigang Huang, Yehai Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00529-6