Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells

Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells

Abstract Background Chemotherapy is the primary established systemic treatment for patients with breast cancer, especially those with the triple-negative subtype. Simultaneously, the resistance of triple-negative breast cancer (TNBC) to chemotherapy remains a major clinical problem. Our previous stu...

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Bibliographic Details
Main Authors: Peng Huang, Deng-jie Ouyang, Shi Chang, Mo-yun Li, Lun Li, Qian-ying Li, Rong Zeng, Qiong-yan Zou, Juan Su, Piao Zhao, Lei Pei, Wen-jun Yi
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Protein tyrosine phosphatase receptor Z1
Pleiotrophin
Chemotherapy resistance
NF-κB signalling pathway
Online Access:http://link.springer.com/article/10.1186/s12964-018-0304-4

Internet

http://link.springer.com/article/10.1186/s12964-018-0304-4

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