The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner.

The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner.

The BRG1 catalytic subunit of SWI/SNF-related complexes is required for mammalian development as exemplified by the early embryonic lethality of Brg1 null homozygous mice. BRG1 is also a tumor suppressor and, in mice, 10% of heterozygous (Brg1(null/+)) females develop mammary tumors. We now demonstr...

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Bibliographic Details
Main Authors: Daniel W Serber, Allison Rogala, Maisam Makarem, Gary B Rosson, Karl Simin, Virginia Godfrey, Terry Van Dyke, Connie J Eaves, Scott J Bultman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3283619?pdf=render

Internet

http://europepmc.org/articles/PMC3283619?pdf=render

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