Neuronal Death in Cultured Murine Cortical Cells Is Induced by Inhibition of GAPDH and Triosephosphate Isomerase

Neuronal Death in Cultured Murine Cortical Cells Is Induced by Inhibition of GAPDH and Triosephosphate Isomerase

Polyglutamine-containing proteins expressed in the CAG repeat diseases Huntington's disease and dentatorubralpallidoluyisian atrophy have recently been suggested to inhibit the key glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). To examine the consequences of GAPDH inhibitio...

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Bibliographic Details
Main Authors: Christian T. Sheline, Dennis W. Choi
Format: Article
Language:English
Published: Elsevier 1998-07-01
Series:Neurobiology of Disease
Subjects:
pyruvate
energy depletion
glycolysis
ATP levels
apoptosis
Huntington's disease.
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996198901772

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http://www.sciencedirect.com/science/article/pii/S0969996198901772

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