Clicked and long spaced galactosyl- and lactosylcalix[4]arenes: new multivalent galectin-3 ligands

Clicked and long spaced galactosyl- and lactosylcalix[4]arenes: new multivalent galectin-3 ligands

Four novel calix[4]arene-based glycoclusters were synthesized by conjugating the saccharide units to the macrocyclic scaffold using the CuAAC reaction and using long and hydrophilic ethylene glycol spacers. Initially, two galactosylcalix[4]arenes were prepared starting from saccharide units and cali...

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Bibliographic Details
Main Authors: Silvia Bernardi, Paola Fezzardi, Gabriele Rispoli, Stefania E. Sestito, Francesco Peri, Francesco Sansone, Alessandro Casnati
Format: Article
Language:English
Published: Beilstein-Institut 2014-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
glycocalixarenes
cluster glycoside effect
multivalency
click chemistry
surface plasmon resonance
Online Access:https://doi.org/10.3762/bjoc.10.175

Internet

https://doi.org/10.3762/bjoc.10.175

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