Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo

Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo

Background: Human sulfatase-1 (Hsulf-1) is an endosulfatase that selectively removes sulfate groups from heparan sulfate proteoglycans (HSPGs), altering the binding of several growth factors and cytokines to HSPG to regulate cell proliferation, cell motility, and apoptosis. We investigated the role...

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Bibliographic Details
Main Authors: Xiao-Ping Yang, Ling Liu, Ping Wang, Sheng-Lin Ma
Format: Article
Language:English
Published: Wolters Kluwer 2015-01-01
Series:Chinese Medical Journal
Subjects:
Cytosine Deaminase/5-Fluorocytosine Suicide System; Hepatocellular Carcinoma; Human Sulfatase-1
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=10;spage=1384;epage=1390;aulast=Yang

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http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=10;spage=1384;epage=1390;aulast=Yang

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