Genistein Activates Transcription Factor EB and Corrects Niemann–Pick C Phenotype

Genistein Activates Transcription Factor EB and Corrects Niemann–Pick C Phenotype

Niemann–Pick type C disease (NPCD) is a lysosomal storage disease (LSD) characterized by abnormal cholesterol accumulation in lysosomes, impaired autophagy flux, and lysosomal dysfunction. The activation of transcription factor EB (TFEB), a master lysosomal function regulator, reduces the accumulati...

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Bibliographic Details
Main Authors: Graciela Argüello, Elisa Balboa, Pablo J. Tapia, Juan Castro, María José Yañez, Pamela Mattar, Rodrigo Pulgar, Silvana Zanlungo
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
Niemann–Pick C
TFEB
genistein
lysosomal storage diseases
cholesterol
lysosome clearance
Online Access:https://www.mdpi.com/1422-0067/22/8/4220

Internet

https://www.mdpi.com/1422-0067/22/8/4220

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