Human pluripotent stem-cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing
Abstract Detailed understanding of the pathogenesis and development of effective therapies for pulmonary fibrosis (PF) have been hampered by lack of in vitro human models that recapitulate disease pathophysiology. In this study, we generated alveolar organoids (AOs) derived from human pluripotent st...
Main Authors: | Jung-Hyun Kim, Geun Ho An, Ji-Young Kim, Roya Rasaei, Woo Jin Kim, Xiong Jin, Dong-Hun Woo, Choongseong Han, Se-Ran Yang, Jong-Hoon Kim, Seok-Ho Hong |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
|
Series: | Cell Death Discovery |
Online Access: | https://doi.org/10.1038/s41420-021-00439-7 |
Similar Items
-
Regulation of JAM2 Expression in the Lungs of Streptozotocin-Induced Diabetic Mice and Human Pluripotent Stem Cell-Derived Alveolar Organoids
by: Roya Rasaei, et al.
Published: (2020-09-01) -
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development
by: Jung-Hyun Kim, et al.
Published: (2020-11-01) -
Generation of human pluripotent stem cell-derived fused organoids with oligodendroglia and myelin
by: Hyosung Kim, et al.
Published: (2021-06-01) -
Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
by: Ho Cheol Kim, et al.
Published: (2021-04-01) -
Dissecting the Niche for Alveolar Type II Cells With Alveolar Organoids
by: Danying Liao, et al.
Published: (2020-06-01)