The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein. Although β3-adrenergic receptor (β3AR) lacks pho...

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Bibliographic Details
Main Authors: Emiliana Echeverría, Maia Cabrera, Valeria Burghi, Máximo Sosa, Sonia Ripoll, Agustín Yaneff, Federico Monczor, Carlos Davio, Carina Shayo, Natalia Fernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
desensitization
GRK2
RGS
β3AR
cardiomyocytes
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00113/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00113/full

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