Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer

Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer

Epithelial-to-mesenchymal transition (EMT) allows epithelial cancer cells to assume mesenchymal features, endowing them with enhanced motility and invasiveness, thus enabling cancer dissemination and metastatic spread. The induction of EMT is orchestrated by EMT-inducing transcription factors that s...

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Bibliographic Details
Main Authors: Flora Guerra, Nicoletta Guaragnella, Arnaldo A. Arbini, Cecilia Bucci, Sergio Giannattasio, Loredana Moro
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Oncology
Subjects:
epithelial-to-mesenchymal transition
mitochondrial dysfunction
mitochondrial DNA
mitochondrial retrograde signaling
metastasis
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00295/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2017.00295/full

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