Deficiency of Adenosine Deaminase 2 in Adult Siblings: Many Years of a Misdiagnosed Disease With Severe Consequences

Deficiency of Adenosine Deaminase 2 in Adult Siblings: Many Years of a Misdiagnosed Disease With Severe Consequences

ObjectiveDescribe the clinical characteristics and histopathology findings in a family with two siblings affected with deficiency of adenosine deaminase 2 (DADA2). Both patients presented in childhood with polyarthritis and developed significant neurological and gastrointestinal features of DADA2 in...

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Bibliographic Details
Main Authors: Jason Michael Springer, Selina A. Gierer, Hong Jiang, David Kleiner, Natalie Deuitch, Amanda K. Ombrello, Peter C. Grayson, Ivona Aksentijevich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
adenosine deaminase 2 deficiency
adenosine deaminase 2
vasculitis
nodular regenerative hyperplasia
stroke
polyarteritis nodosa
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01361/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01361/full

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