CD1d-Dependent iNKT Cells Control DSS-Induced Colitis in a Mouse Model of IFNγ-Mediated Hyperinflammation by Increasing IL22-Secreting ILC3 Cells

CD1d-Dependent iNKT Cells Control DSS-Induced Colitis in a Mouse Model of IFNγ-Mediated Hyperinflammation by Increasing IL22-Secreting ILC3 Cells

We have previously shown that CD1d-restricted iNKT cells suppress dysregulated IFNγ expression and intestinal inflammation in Yeti mice on the C57BL/6 background. Since type 3 innate lymphoid cells (ILC3s) in mesenteric lymph nodes (MLN) protect against intestinal inflammation in a CD1d-associated m...

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Bibliographic Details
Main Authors: Hyun Jung Park, Sung Won Lee, Luc Van Kaer, Seokmann Hong
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
iNKT cells
CD1d
IFNγ
ILC3
IL22
Online Access:https://www.mdpi.com/1422-0067/22/3/1250

Internet

https://www.mdpi.com/1422-0067/22/3/1250

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