Antibody protection reveals extended epitopes on the human TSH receptor.

Antibody protection reveals extended epitopes on the human TSH receptor.

Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-dependent epitopes reported to involve primarily the leucine rich repeat region of the ectodomain (LRD). However, successful crystallization of TSHR residues 22-260 has omitted important extracellular non-LRD res...

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Bibliographic Details
Main Authors: Rauf Latif, Avelino Teixeira, Krzysztof Michalek, M Rejwan Ali, Max Schlesinger, Ramkumarie Baliram, Syed A Morshed, Terry F Davies
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3434159?pdf=render

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http://europepmc.org/articles/PMC3434159?pdf=render

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