Deletion of Osteopontin Enhances β<sub>2</sub>-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes

Deletion of Osteopontin Enhances β<sub>2</sub>-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes

Cardiac &#946;<sub>2</sub>-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in cardiac fibroblasts and myocytes. The &#946;<sub>2</sub>AR is a Gs protein-coupled receptor (GPCR) and, upon its activation, stimulates the generation of cyc...

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Bibliographic Details
Main Authors: Celina M. Pollard, Victoria L. Desimine, Shelby L. Wertz, Arianna Perez, Barbara M. Parker, Jennifer Maning, Katie A. McCrink, Lina A. Shehadeh, Anastasios Lymperopoulos
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
β<sub>2</sub>-adrenergic receptor
cAMP
cardiac myocytes
CRISPR
Epac1
fibrosis
osteopontin
signal transduction
Online Access:https://www.mdpi.com/1422-0067/20/6/1396

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https://www.mdpi.com/1422-0067/20/6/1396

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