HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets

Background. Fructose metabolism is an unregulated metabolic pathway and excessive fructose consumption is known to activate ROS. HO-1 is a potent antioxidant gene that plays a key role in decreasing ROS and isoprostanes. We examined whether the fructose-mediated increase in adipocyte dysfunction inv...

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Bibliographic Details
Main Authors: Zeid Khitan, Mohit Harsh, Komal Sodhi, Joseph I. Shapiro, Nader G. Abraham
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2014/980547