Nanoparticles containing siRNA to silence CD4 and CCR5 reduce expression of these receptors and inhibit HIV-1 infection in human female reproductive tract tissue explants

Nanoparticles containing siRNA to silence CD4 and CCR5 reduce expression of these receptors and inhibit HIV-1 infection in human female reproductive tract tissue explants

Human Immunodeficiency Virus-type 1 (HIV- 1) binds to CD4 and CCR5 receptors on target cells in the human female reproductive tract. We sought to determine whether reducing levels of messenger RNA (mRNA) transcripts that encode these receptors in female reproductive tract cells could protect mucosal...

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Bibliographic Details
Main Authors: Susan K. Eszterhas, Nicole O. Ilonzo, Jennifer E. Crozier, Stela Celaj, Alexandra L. Howell
Format: Article
Language:English
Published: MDPI AG 2011-09-01
Series:Infectious Disease Reports
Subjects:
heterosexual transmission, women, virus infection, HIV-1, nanoparticles.
Online Access:http://www.pagepress.org/journals/index.php/idr/article/view/2370

Internet

http://www.pagepress.org/journals/index.php/idr/article/view/2370

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