Reduced treatment frequencies with bumped kinase inhibitor 1369 are effective against porcine cystoisosporosis

Reduced treatment frequencies with bumped kinase inhibitor 1369 are effective against porcine cystoisosporosis

Bumped kinase inhibitors (BKIs) are a new class of antiprotozoal drugs that target calcium-dependent protein kinase 1 (CDPK1) in various apicomplexan parasites. A multiple dose regimen of BKI 1369 has been shown to be highly effective against Cystoisospora suis (syn. Isospora suis), the causative ag...

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Bibliographic Details
Main Authors: Aruna Shrestha, Bärbel Ruttkowski, Patricia Greber, Grant R. Whitman, Matthew A. Hulverson, Ryan Choi, Samantha A. Michaels, Kayode K. Ojo, Wesley C. Van Voorhis, Anja Joachim
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Isospora suis
Oocyst excretion
CDPK1
Growth inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320720300257

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http://www.sciencedirect.com/science/article/pii/S2211320720300257

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