The Role of Nitric Oxide in the Dysregulation of the Urine Concentration Mechanism in Diabetes Mellitus

The Role of Nitric Oxide in the Dysregulation of the Urine Concentration Mechanism in Diabetes Mellitus

Uncontrolled diabetes mellitus results in osmotic diuresis. Diabetic patients have lowered nitric oxide (NO) which may exacerbate polyuria. We examined how lack of NO affects the transporters involved in urine concentration in diabetic animals. Diabetes was induced in rats by streptozotocin. Con...

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Bibliographic Details
Main Authors: Penelope eCipriani, Sunhye L Kim, Janet D. Klein, Jae H Sim, Tobias N von Bergen, Mitsi A Blount
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Physiology
Subjects:
Diabetes Mellitus
urine concentration
osmotic diuresis
urea transporter
aquaporin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00176/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00176/full

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