Transgenic mice over-expressing GABABR1a receptors acquire an atypical absence epilepsy-like phenotype

Transgenic mice over-expressing GABABR1a receptors acquire an atypical absence epilepsy-like phenotype

In this study, we tested whether over-expressing the GABAB receptor R1a subtype in transgenic mouse forebrain neurons would be sufficient to induce spontaneous absence seizures. As hypothesized, these transgenic mice develop spontaneous, recurrent, bilaterally synchronous, 3–6 Hz slow spike and wave...

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Bibliographic Details
Main Authors: Ying Wu, Katherine F.Y. Chan, James H. Eubanks, C. Guin Ting Wong, Miguel A. Cortez, Liqing Shen, Chun Che Liu, Jose Perez Velazquez, Yu Tian Wang, Zhengping Jia, O. Carter Snead, III
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Neurobiology of Disease
Subjects:
Absence seizures
Epileptogenesis
GABAB receptor
Transgenic Mouse
Neurophysiology
Behavior
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000307

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http://www.sciencedirect.com/science/article/pii/S0969996107000307

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