Therapeutic Landscape of Malignant Pleural Mesothelioma: Collateral Vulnerabilities and Evolutionary Dependencies in the Spotlight

Therapeutic Landscape of Malignant Pleural Mesothelioma: Collateral Vulnerabilities and Evolutionary Dependencies in the Spotlight

Malignant pleural mesothelioma (MPM) is the epitome of a recalcitrant cancer driven by pharmacologically intractable tumor suppressor proteins. A significant but largely unmet challenge in the field is the translation of genetic information on alterations in tumor suppressor genes (TSGs) into effect...

Full description

Bibliographic Details
Main Authors: Duo Xu, Haitang Yang, Ralph A. Schmid, Ren-Wang Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
malignant pleural mesothelioma
tumor suppressors
collateral and evolutionary vulnerabilities
targeted therapy
CRISPR/Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.579464/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.579464/full

Similar Items