Pyruvate alleviates high glucose‐induced endoplasmic reticulum stress and apoptosis in HK‐2 cells

Pyruvate alleviates high glucose‐induced endoplasmic reticulum stress and apoptosis in HK‐2 cells

Endoplasmic reticulum (ER) stress plays a critical role in the development of diabetic nephropathy (DN). We previously demonstrated that pyruvate (Pyr)‐enriched oral rehydration solution improved glucometabolic disorders and ameliorated DN outcome in db/db mice. Here, we investigated the effects of...

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Bibliographic Details
Main Authors: Xiao Meng Zhang, Yi Zhen Wang, Jin Dong Tong, Xu Chao Ning, Fang Qiang Zhou, Xiu Hong Yang, Hui Min Jin
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:FEBS Open Bio
Subjects:
apoptosis
diabetes
diabetic nephropathy
endoplasmic reticulum stress
HK‐2 cells
pyruvate
Online Access:https://doi.org/10.1002/2211-5463.12834

Internet

https://doi.org/10.1002/2211-5463.12834

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