Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

Abstract Background There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential to cost-efficiently accelerate precision medicine trials to improve...

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Bibliographic Details
Main Authors: Markus Mayrhofer, Bram De Laere, Tom Whitington, Peter Van Oyen, Christophe Ghysel, Jozef Ampe, Piet Ost, Wim Demey, Lucien Hoekx, Dirk Schrijvers, Barbara Brouwers, Willem Lybaert, Els Everaert, Daan De Maeseneer, Michiel Strijbos, Alain Bols, Karen Fransis, Steffi Oeyen, Pieter-Jan van Dam, Gert Van den Eynden, Annemie Rutten, Markus Aly, Tobias Nordström, Steven Van Laere, Mattias Rantalainen, Prabhakar Rajan, Lars Egevad, Anders Ullén, Jeffrey Yachnin, Luc Dirix, Henrik Grönberg, Johan Lindberg
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Medicine
Subjects:
Circulating tumor DNA
Metastatic prostate cancer
Microsatellite instability
Structural rearrangement
Clonal hematopoiesis
Online Access:http://link.springer.com/article/10.1186/s13073-018-0595-5

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http://link.springer.com/article/10.1186/s13073-018-0595-5

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