A T Cell Receptor Sequencing-Based Assay Identifies Cross-Reactive Recall CD8+ T Cell Clonotypes Against Autologous HIV-1 Epitope Variants

A T Cell Receptor Sequencing-Based Assay Identifies Cross-Reactive Recall CD8+ T Cell Clonotypes Against Autologous HIV-1 Epitope Variants

HIV-1 positive elite controllers or suppressors control viral replication without antiretroviral therapy, likely via CTL-mediated elimination of infected cells, and therefore represent a model of an HIV-1 functional cure. Efforts to cure HIV-1 accordingly rely on the existence or generation of antig...

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Bibliographic Details
Main Authors: Hok Yee Chan, Jiajia Zhang, Caroline C. Garliss, Abena K. Kwaa, Joel N. Blankson, Kellie N. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
HIV
cure
elite suppressors
elite controllers
clonotype
CD8 lymphocytes+
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00591/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00591/full

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