An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic reticulum (ER). Antagonizing action of the Ca...

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Bibliographic Details
Main Authors: Bethan S. Kilpatrick, Emily R. Eden, Leanne N. Hockey, Elizabeth Yates, Clare E. Futter, Sandip Patel
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
NAADP
Ca2+
TPC1
membrane contact sites
endosomes
endoplasmic reticulum
EGF
TPC2
lysosomes
acidic Ca2+ stores
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301092

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http://www.sciencedirect.com/science/article/pii/S2211124717301092

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