Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation

Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation

Summary: Activating mutations in the canonical Wnt/β-catenin pathway are key drivers of hyperplasia, the gateway for tumor development. In a wide range of tissues, this occurs primarily through enhanced effects on cellular proliferation. Whether additional mechanisms contribute to β-catenin-driven h...

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Bibliographic Details
Main Authors: Emanuele Pignatti, Sining Leng, Yixing Yuchi, Kleiton S. Borges, Nick A. Guagliardo, Manasvi S. Shah, Gerard Ruiz-Babot, Dulanjalee Kariyawasam, Makoto Mark Taketo, Ji Miao, Paula Q. Barrett, Diana L. Carlone, David T. Breault
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720304241

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http://www.sciencedirect.com/science/article/pii/S2211124720304241

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