Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats

Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats

Abstract Gadolinium based contrast agents (GBCAs) are widely used in clinical MRI since the mid-1980s. Recently, concerns have been raised that trace amounts of Gadolinium (Gd), detected in brains even long time after GBCA application, may cause yet unrecognized clinical consequences. We therefore a...

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Bibliographic Details
Main Authors: Johanna Habermeyer, Janina Boyken, Julia Harrer, Fabio Canneva, Veronika Ratz, Sandra Moceri, Jakob Admard, Nicolas Casadei, Gregor Jost, Tobias Bäuerle, Thomas Frenzel, Christoph Schmitz, Gunnar Schütz, Hubertus Pietsch, Stephan von Hörsten
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79374-z

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https://doi.org/10.1038/s41598-020-79374-z

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