A KDM4-DBC1-SIRT1 Axis Contributes to TGF-b Induced Mesenchymal Transition of Intestinal Epithelial Cells

A KDM4-DBC1-SIRT1 Axis Contributes to TGF-b Induced Mesenchymal Transition of Intestinal Epithelial Cells

Intestinal fibrosis is one of the common pathophysiological processes in inflammatory bowel diseases (IBDs). Previously it has been demonstrated that epithelial-mesenchymal transition (EMT) can contribute to the development of intestinal fibrosis. Here we report that conditional ablation of SIRT1, a...

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Bibliographic Details
Main Authors: Baoyu Chen, Wenhui Dong, Tinghui Shao, Xiulian Miao, Yan Guo, Xingyu Liu, Yifei Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intestinal fibrosis
epithelial-mesenchymal transition
SIRT1
transcriptional regulation
epigenetics
histone demethylase
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.697614/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.697614/full

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