Alpha-Bulges in G Protein-Coupled Receptors

Alpha-Bulges in G Protein-Coupled Receptors

Agonist binding is related to a series of motions in G protein-coupled receptors (GPCRs) that result in the separation of transmembrane helices III and VI at their cytosolic ends and subsequent G protein binding. A large number of smaller motions also seem to be associated with activation. Most heli...

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Bibliographic Details
Main Authors: Rob van der Kant, Gert Vriend
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
GPCR
π-helix
α-bulge
GPCR activation
random forest
structure-function
Online Access:http://www.mdpi.com/1422-0067/15/5/7841

Internet

http://www.mdpi.com/1422-0067/15/5/7841

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