The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis

The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis

UVB radiation is the most mutagenic component of the UV spectrum that reaches the earth’s surface and causes the development of DNA damage in the form of cyclobutane pyrimidine dimers and 6-4 photoproducts. UV radiation usually results in cellular death, but if left unchecked, it can a...

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Bibliographic Details
Main Authors: Timothy Budden, Nikola A. Bowden
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
ultraviolet light
UVB
DNA damage
6-4 photoproducts
cyclobutane pyrimidine dimers
DNA repair
nucleotide excision repair
cell death
apoptosis
melanoma
Online Access:http://www.mdpi.com/1422-0067/14/1/1132

Internet

http://www.mdpi.com/1422-0067/14/1/1132

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