Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway.

Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway.

We have previously shown increased cardiac stanniocalcin-1 (STC1) in patients with idiopathic dilated cardiomyopathy. STC1 localizes to the inner mitochondrial membrane and transgenic over-expression of STC1 is associated with increased energy utilization.We examined the hypothesis that STC1 uncoupl...

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Bibliographic Details
Main Authors: Dajun Liu, Luping Huang, Yanlin Wang, Wei Wang, Xander H T Wehrens, Tatiana Belousova, Maen Abdelrahim, Gabriel DiMattia, David Sheikh-Hamad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3365029?pdf=render

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http://europepmc.org/articles/PMC3365029?pdf=render

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