High-frequency spinal cord stimulation produces long-lasting analgesic effects by restoring lysosomal function and autophagic flux in the spinal dorsal horn

High-frequency spinal cord stimulation produces long-lasting analgesic effects by restoring lysosomal function and autophagic flux in the spinal dorsal horn

High-frequency spinal cord stimulation (HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat neuropathic pain was induced by spinal nerve ligation. Two days after modeling, the...

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Bibliographic Details
Main Authors: Zhi-Bin Wang, Yong-Da Liu, Shuo Wang, Ping Zhao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
autolysosome; dorsal horn of spinal cord; dysfunction; electrical stimulation; high-frequency spinal cord stimulation; neuropathic pain; spinal nerve ligation
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=2;spage=370;epage=377;aulast=Wang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=2;spage=370;epage=377;aulast=Wang

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