Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children.

Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children.

HIV-1 subtype B replication in the CNS can occur in CD4+ T cells or macrophages/microglia in adults. However, little is known about CNS infection in children or the ability of subtype C HIV-1 to evolve macrophage-tropic variants. In this study, we examined HIV-1 variants in ART-naïve children aged t...

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Bibliographic Details
Main Authors: Christa Buckheit Sturdevant, Anna Dow, Cassandra B Jabara, Sarah B Joseph, Gretja Schnell, Nobutoki Takamune, Macpherson Mallewa, Robert S Heyderman, Annelies Van Rie, Ronald Swanstrom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3531524?pdf=render

Internet

http://europepmc.org/articles/PMC3531524?pdf=render

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