Preemptive Homology-Directed DNA Repair Fosters Complex Genomic Rearrangements in Hepatocellular Carcinoma

Degree of genomic instability closely correlates with poor prognosis, drug resistance as well as poor survival across human cancer of different origins. This study assessed the relationship between DNA damage response (DDR) and chromosome instability in hepatocellular carcinoma (HCC). We investigate...

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Bibliographic Details
Main Authors: Shirley Ming-Hui Sy, Yingying Guo, Ying Lan, Howin Ng, Michael Shing-Yan Huen
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320300280