Morniga-G, a T/Tn-Specific Lectin, Induces Leukemic Cell Death via Caspase and DR5 Receptor-Dependent Pathways

Morniga-G, a T/Tn-Specific Lectin, Induces Leukemic Cell Death via Caspase and DR5 Receptor-Dependent Pathways

Morniga-G, the Gal-specific black mulberry (Morus nigra) lectin, displays high affinity for T (CD176) and Tn (CD175) antigens, frequently expressed at the cancer cell surface. The effects of Morniga-G were investigated on a Tn-positive leukemic Jurkat cell line. The lectin, used in a concentration r...

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Bibliographic Details
Main Authors: Guillaume Poiroux, Annick Barre, Mathias Simplicien, Sandrine Pelofy, Bruno Segui, Els J. M. Van Damme, Pierre Rougé, Hervé Benoist
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
plant lectin
Morniga-G
O-glycosylation
T/Tn antigen
Jurkat cells
cancer cell death
apoptosis
TRAIL/DR5 pathway
Online Access:http://www.mdpi.com/1422-0067/20/1/230

Internet

http://www.mdpi.com/1422-0067/20/1/230

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