AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner

AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner

Absent in melanoma 2 (AIM2), a DNA sensor that plays an important role in natural immunity system, has been reported to participate in colorectal cancer (CRC) development. However, the functional role of AIM2 in BRAF-mutant CRC remains unclear. In this study, we first investigated AIM2 expression le...

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Bibliographic Details
Main Authors: Shailendra Shah, Shaolan Qin, Yang Luo, Yizhou Huang, Ran Jing, Jay N. Shah, Jianjun Chen, Huimin Chen, Ming Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
colorectal cancer
BRAF-mutant
absent in melanoma 2
caspase-1
patient-derived organoids
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.588278/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.588278/full

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