ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation

ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation

Activation of the epidermal growth factor receptor (EGFR) is crucial for development, tissue homeostasis, and immunity. Dysregulation of EGFR signaling is associated with numerous diseases. EGFR ubiquitination and endosomal trafficking are key events that regulate the termination of EGFR signaling,...

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Bibliographic Details
Main Authors: Chia-Hsing Shen, Chih-Chang Chou, Ting-Yu Lai, Jer-En Hsu, You-Sheng Lin, Huai-Yu Liu, Yan-Kai Chen, I-Lin Ho, Pang-Hung Hsu, Tsung-Hsien Chuang, Chih-Yuan Lee, Li-Chung Hsu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ZNRF1
epidermal growth factor receptor (EGFR)
ubiquitination
lysosomal trafficking
herpes simplex virus 1 (HSV-1)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.642625/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.642625/full

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