Sequence-dependent synergistic cytotoxicity of icotinib and pemetrexed in human lung cancer cell lines in vitro and in vivo

Sequence-dependent synergistic cytotoxicity of icotinib and pemetrexed in human lung cancer cell lines in vitro and in vivo

Abstract Background Recent Clinical trials of administration of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in combination with standard first-line chemotherapy have failed to improve survival in patients with advanced NSCLC, However, the sequential treatment with EGFR-TK...

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Bibliographic Details
Main Authors: Tianze Liu, Lizi Jin, Wenjing Lu, Hairun Gan, Zhidong Lin, Miao Chen, Jiani Liu, Fan Zhang, Siyang Wang, Hongyu Zhang, Wuguo Deng, Hongtao Chen
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Icotinib
Lung cancer
EGFR mutation
Synergy
Washout period
Online Access:http://link.springer.com/article/10.1186/s13046-019-1133-z

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http://link.springer.com/article/10.1186/s13046-019-1133-z

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