A novel automated image analysis pipeline for quantifying morphological changes to the endoplasmic reticulum in cultured human cells

Abstract Background In mammalian cells the endoplasmic reticulum (ER) comprises a highly complex reticular morphology that is spread throughout the cytoplasm. This organelle is of particular interest to biologists, as its dysfunction is associated with numerous diseases, which often manifest themsel...

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Bibliographic Details
Main Authors: M. Elena Garcia-Pardo, Jeremy C. Simpson, Niamh C. O’Sullivan
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-021-04334-x