The WD40 domain is required for LRRK2 neurotoxicity.

The WD40 domain is required for LRRK2 neurotoxicity.

BACKGROUND:Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson disease (PD). LRRK2 contains an "enzymatic core" composed of GTPase and kinase domains that is flanked by leucine-rich repeat (LRR) and WD40 protein-protein interaction domains. Whil...

Full description

Bibliographic Details
Main Authors: Nathan D Jorgensen, Yong Peng, Cherry C-Y Ho, Hardy J Rideout, Donald Petrey, Peng Liu, William T Dauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2794542?pdf=render

Internet

http://europepmc.org/articles/PMC2794542?pdf=render

Similar Items