Long-Term Anti-Allodynic Effect of Immediate Pulsed Radiofrequency Modulation through Down-Regulation of Insulin-Like Growth Factor 2 in a Neuropathic Pain Model

Long-Term Anti-Allodynic Effect of Immediate Pulsed Radiofrequency Modulation through Down-Regulation of Insulin-Like Growth Factor 2 in a Neuropathic Pain Model

Pulsed radiofrequency (PRF) is effective in the treatment of neuropathic pain in clinical practice. Its application to sites proximal to nerve injury can inhibit the activity of extra-cellular signal-regulated kinase (ERK) for up to 28 days. The spared nerve injury (SNI)+ immPRF group (immediate exp...

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Bibliographic Details
Main Authors: Chun-Chang Yeh, Hsiao-Lun Sun, Chi-Jung Huang, Chih-Shung Wong, Chen-Hwan Cherng, Billy Keon Huh, Jinn-Shyan Wang, Chih-Cheng Chien
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
pulsed radiofrequency
spared nerve injury
extra-cellular signal-regulated kinase 1/2
Insulin-like growth factor II
gene ontology annotations
Online Access:http://www.mdpi.com/1422-0067/16/11/26013

Internet

http://www.mdpi.com/1422-0067/16/11/26013

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