Metabolic Abnormalities Detected in Phase II Evaluation of Doxycycline in Dogs with Multicentric B-Cell Lymphoma

Doxycycline has antiproliferative effects in human lymphoma cells and in murine xenografts. We hypothesized that doxycycline would decrease canine lymphoma cell viability and prospectively evaluated its clinical tolerability in client-owned dogs with spontaneous, nodal, multicentric, substage a, B-c...

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Bibliographic Details
Main Authors: Kelly R. Hume, Skylar R. Sylvester, Lucia Borlle, Cheryl E. Balkman, Angela L. McCleary-Wheeler, Mary Pulvino, Carla Casulo, Jiyong Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Veterinary Science
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fvets.2018.00025/full