Case Report: Hyper IgM Syndrome Identified by Whole Genome Sequencing in a Young Syrian Man Presenting With Atypical, Severe and Recurrent Mucosal Leishmaniasis

Case Report: Hyper IgM Syndrome Identified by Whole Genome Sequencing in a Young Syrian Man Presenting With Atypical, Severe and Recurrent Mucosal Leishmaniasis

A previously healthy 19-year-old Syrian man presented with atypical and severe mucosal leishmaniasis caused by Leishmania tropica. During a 2-year period, he had three severe relapses despite various treatment strategies, including liposomal amphotericin B and Miltefosine. Because of the unusual cli...

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Bibliographic Details
Main Authors: Camilla Heldbjerg Drabe, Rasmus L. Marvig, Line Borgwardt, Jens D. Lundgren, Hanne Vibeke Hansen Maquart, Terese Lea Katzenstein, Marie Helleberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
immunodeficiency
leishmaniasis
hyper IgM syndrome
genetics
diagnostic
whole genome sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.567856/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.567856/full

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