Exploration of the Molecular Mechanism for Lipoprotein Lipase Expression Variations in SH-SY5Y Cells Exposed to Different Doses of Amyloid-Beta Protein

Exploration of the Molecular Mechanism for Lipoprotein Lipase Expression Variations in SH-SY5Y Cells Exposed to Different Doses of Amyloid-Beta Protein

Progressive accumulation of amyloid-β (Aβ) plaques in the brain is a characteristic pathological change in Alzheimer’s disease (AD). We previously found the expression of lipoprotein lipase (LPL) was increased in SH-SY5Y cells exposed to low-dose Aβ and decreased in cells with high-dose Aβ exposure,...

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Bibliographic Details
Main Authors: Jingzhu Zhang, Yufan Liu, Sihui Wang, Ran Que, Weidong Zhao, Li An
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
amyloid-β
lipoprotein lipase
histone deacetylase 2
histone deacetylase 3
microRNA-29a
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00132/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00132/full

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