Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint

Abstract Background In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect is significant or for futility when th...

Full description

Bibliographic Details
Main Authors: Xieran Li, Carolin Herrmann, Geraldine Rauch
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12874-020-01141-5