Erk5 Mediates TGFβ1-induced Loss of Phenotype and Function in Human Podocytes

Diabetic nephropathy is one of the most common causes of renal impairment. Podocytes are specialised cells integral to normal kidney physiology, however in diabetes injury occurs leading to compromised function which is a critical factor in the development of the disease. TGFβ1 is known to play a ma...

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Bibliographic Details
Main Authors: Irbaz Isaac Badshah, Deborah L Baines, Mark Edward Dockrell
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00071/full