Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate

Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate

Beta-catenin (CTNNB1) directs ectodermal appendage spacing by activating ectodysplasin A receptor (EDAR) transcription, but whether CTNNB1 acts by a similar mechanism in the prostate, an endoderm-derived tissue, is unclear. Here we examined the expression, function, and CTNNB1 dependence of the EDAR...

Full description

Bibliographic Details
Main Authors: Kyle A. Wegner, Vatsal Mehta, Jeanette A. Johansson, Brett R. Mueller, Kimberly P. Keil, Lisa L. Abler, Paul C. Marker, M. Mark Taketo, Denis J. Headon, Chad M. Vezina
Format: Article
Language:English
Published: The Company of Biologists 2019-03-01
Series:Biology Open
Subjects:
Prostate
Urogenital sinus
CTNNB1
WNT10B
EDAR
Collagen
Online Access:http://bio.biologists.org/content/8/3/bio037945

Internet

http://bio.biologists.org/content/8/3/bio037945

Similar Items